产品货号：
Z10286
中文名称：
AAK1抗体
英文名称：
Anti-AAK1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AAK1 Antibody |
| 指标别名 | KIAA1048;AP2-associated protein kinase 1;Adaptor-associated kinase 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | AAK1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Aak1 antibody was raised against a 20 amino acid synthetic peptide near the amino terminus of the human Aak1.The immunogen is located within amino acids 190 - 240 of Aak1. |
| 计算分子量 | 104kDa |
| 成分 | Aak1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Aak1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components.Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex,which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis.At least two isoforms of Aak1 are known to exist;the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain.Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome,suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane. |
| Uniprot ID | Q2M2I8 |
| 基因名全称 | AP2 associated kinase 1 |
| 蛋白名全称 | AP2 associated kinase 1 |
| 推荐稀释比 | Aak1 antibody can be used for detection of Aak1 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunocytochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunocytochemistry in mouse samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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